Rotavirus vaccine (live, oral) is given to a 6-week-old infant. The MOST important contraindication that must be checked before administering the first dose is:

• A Prior rotavirus gastroenteritis episode
• B History of previous intussusception ✓
• C Preterm birth at <34 weeks
• D Maternal HIV status unknown

Explanation

A history of intussusception is an absolute contraindication to rotavirus vaccine because administration in a child with a pre-existing anatomic risk (including prior intussusception) could precipitate recurrence. The original rotavirus vaccine (RotaShield) was withdrawn due to intussusception risk; current vaccines (Rotarix, RotaTeq) have a small but real risk especially if given after 12 weeks for first dose, which is why an age cap exists. Prior rotavirus infection is not a contraindication (may reduce immunogenicity but not harmful). Preterm birth is not a contraindication. Rotavirus vaccines are given to HIV-exposed and HIV-positive infants in many guidelines.

Reference: Ghai Essential Pediatrics, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.