A 9-month-old child with known HIV infection (asymptomatic, CD4% 28%) is brought for vaccination. Which of the following vaccines is CONTRAINDICATED in this child?
- A Yellow fever vaccine ✓
- B Measles vaccine
- C Hepatitis B vaccine
- D Pneumococcal conjugate vaccine (PCV)
Correct answer: A. Yellow fever vaccine
Explanation
Yellow fever vaccine (live attenuated) is contraindicated in HIV-infected individuals regardless of CD4 count, due to risk of vaccine-associated viscerotropic disease. Measles vaccine can be given to asymptomatic HIV-positive children with CD4% ≥15% (WHO guidelines) because the risk of measles disease far outweighs vaccine risk at this immunological status; at CD4% 28% it is indicated. Hepatitis B and PCV13 are inactivated/subunit vaccines and are recommended in HIV-positive children. BCG is contraindicated if symptomatic HIV.
Reference: Ghai Essential Pediatrics, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.