In the Indian National Immunization Schedule (NIS), Inactivated Poliovirus Vaccine (IPV) has been introduced at specific ages. Which statement about the COMBINATION of OPV and IPV is MOST accurate under the current NIS?
- A IPV replaces all OPV doses; OPV is no longer used
- B IPV is given as two fractional intradermal doses at 6 and 14 weeks, in addition to OPV at birth, 6, 10, and 14 weeks ✓
- C IPV is given at 6 weeks only as a single full intramuscular dose
- D OPV is discontinued at 6 months once IPV is administered
Correct answer: B. IPV is given as two fractional intradermal doses at 6 and 14 weeks, in addition to OPV at birth, 6, 10, and 14 weeks
Explanation
Under the current Indian NIS, OPV is given at birth (bOPV) and at 6, 10, and 14 weeks (bivalent OPV). IPV is administered as two fractional intradermal doses (0.1 mL each) at 6 weeks and 14 weeks, given simultaneously with DPT and OPV. This fractional-dose intradermal schedule achieves similar seroconversion as full intramuscular doses while conserving vaccine supply. OPV is NOT discontinued — both are used together to maximize mucosal and humoral immunity, an important distinction for sequential vaccination strategy.
Reference: Ghai Essential Pediatrics, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.