A 35-year-old woman with nephrotic syndrome and a history of recurrent venous thromboembolism is found to have membranous nephropathy. Which thrombotic complication is most specifically associated with membranous nephropathy?

• A Deep vein thrombosis of lower limbs
• B Renal vein thrombosis ✓
• C Pulmonary embolism
• D Cerebral venous sinus thrombosis

Explanation

Renal vein thrombosis is the most characteristic thrombotic complication of membranous nephropathy, occurring due to urinary loss of antithrombin III and other anticoagulant factors combined with increased procoagulant synthesis. While DVT and PE can occur, renal vein thrombosis is the most specific and classic association. Membranous nephropathy carries the highest thrombotic risk among nephrotic syndromes.

Reference: Brenner and Rector's The Kidney, 11th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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