A 10-year-old boy develops hematuria, edema and hypertension two weeks after streptococcal throat infection. Renal biopsy shows subepithelial 'hump-shaped' immune deposits on electron microscopy and granular IgG/C3 deposits on immunofluorescence. This pattern is most consistent with:
- A Acute post-streptococcal glomerulonephritis ✓
- B IgA nephropathy (Berger's disease)
- C Membranous nephropathy
- D Alport syndrome
Correct answer: A. Acute post-streptococcal glomerulonephritis
Explanation
Post-streptococcal GN presents 10–21 days after Group A beta-hemolytic streptococcal pharyngitis with nephritic syndrome. The pathological hallmark is subepithelial 'hump-shaped' electron-dense deposits (streptococcal antigen-antibody complexes) and granular ('lumpy-bumpy') IgG and C3 immunofluorescence. IgA nephropathy shows mesangial IgA deposits. Membranous nephropathy shows subepithelial deposits forming 'spikes' on silver stain. Alport syndrome shows thinning/splitting of the GBM.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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