Focal segmental glomerulosclerosis (FSGS) on biopsy shows sclerosis affecting some glomeruli (focal) and only part of each affected glomerulus (segmental). The FSGS variant associated with highest risk of recurrence after renal transplantation is:
- A Perihilar variant
- B Collapsing variant ✓
- C Tip lesion variant
- D Cellular variant
Correct answer: B. Collapsing variant
Explanation
Collapsing FSGS (associated with HIV nephropathy and parvovirus B19 infection) carries the worst prognosis and the highest rate of recurrence post-transplantation, suggesting a circulating permeability factor etiology. The tip lesion variant has the best prognosis and lowest recurrence rate. Perihilar and cellular variants are intermediate. Post-transplant recurrence rate for primary FSGS is ~30-40% overall but collapsing has the highest rate.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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