Which combination of immunofluorescence findings correctly defines the three categories of rapidly progressive glomerulonephritis?
- A All three types show granular deposits differing only in immunoglobulin class
- B Type I granular deposits, Type II linear IgG, Type III full house staining
- C Type I linear IgG, Type II granular deposits, Type III little or no deposition ✓
- D All three types are pauci-immune and differ only by serologic markers
Correct answer: C. Type I linear IgG, Type II granular deposits, Type III little or no deposition
Explanation
Type I RPGN is anti-GBM disease with smooth linear IgG along the basement membranes. Type II is immune complex mediated, as in lupus, post-infectious, or IgA nephropathy, and shows granular deposits. Type III is pauci-immune, usually ANCA associated, with little or no immunoglobulin staining. Option B swaps the first two patterns, and options A and D ignore the defining immunopathologic differences used in standard classifications.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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