Goodpasture syndrome causes rapidly progressive glomerulonephritis by which immune mechanism?

• A Immune complex deposition (granular pattern on IF)
• B Pauci-immune crescentic GN with ANCA positivity
• C Anti-GBM antibodies against alpha-3 chain of type IV collagen (linear IgG on IF) ✓
• D Complement-mediated lysis via alternative pathway without antibody

Explanation

Goodpasture syndrome is caused by IgG autoantibodies directed against the non-collagenous (NC1) domain of the alpha-3 chain of type IV collagen in the GBM. Immunofluorescence shows a characteristic LINEAR IgG pattern along the GBM (and alveolar basement membranes). ANCA-associated vasculitis causes pauci-immune crescentic GN with minimal deposits.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.