Anti-GBM antibody disease (Goodpasture syndrome) targets which specific antigen in the glomerular basement membrane?
- A Non-collagenous domain 1 of the alpha-3 chain of type IV collagen ✓
- B Phospholipase A2 receptor (PLA2R)
- C Laminin beta-2 chain
- D Heparan sulfate proteoglycan
Correct answer: A. Non-collagenous domain 1 of the alpha-3 chain of type IV collagen
Explanation
Goodpasture syndrome is caused by autoantibodies targeting the non-collagenous (NC1) domain of the alpha-3 chain of type IV collagen, a component present in glomerular and alveolar basement membranes. This explains the pulmonary-renal syndrome. Immunofluorescence shows a characteristic linear IgG pattern along the GBM. PLA2R is the target antigen in primary membranous nephropathy. Laminin beta-2 mutations cause Pierson syndrome, a congenital nephrotic syndrome.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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