A 28-year-old man presents with haematuria, red cell casts, hypertension, and mild oliguria 2 weeks after a sore throat. Serum C3 is low and ASO titre is elevated. The renal biopsy finding most likely to be seen is:

• A Diffuse endocapillary hypercellularity with subepithelial 'hump' deposits on electron microscopy ✓
• B Segmental sclerosis and hyalinosis affecting some glomeruli with foot process effacement
• C Mesangial IgA deposits with focal segmental endocapillary proliferation
• D Crescentic GN with linear IgG along the GBM on immunofluorescence

Explanation

The clinical picture describes post-streptococcal (post-infectious) GN — nephritic syndrome 1–3 weeks after streptococcal pharyngitis with hypocomplementemia (low C3) and elevated ASO. Biopsy shows diffuse endocapillary hypercellularity on LM and pathognomonic subepithelial electron-dense 'hump' deposits on EM with granular IgG and C3 on IF. FSGS lacks the post-infectious context; Goodpasture disease shows linear IgG.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.