Skin biopsy of a patient with blistering disease shows: subepidermal blister, eosinophil-rich inflammatory infiltrate, and linear IgG + C3 along the basement membrane zone on DIF. Which diagnosis does this support?

• A Dermatitis herpetiformis
• B Pemphigus vulgaris
• C Linear IgA disease
• D Bullous pemphigoid ✓

Explanation

Bullous pemphigoid shows subepidermal blistering with an eosinophil-rich infiltrate on H&E and linear IgG + C3 at the dermoepidermal junction on DIF. DH shows granular IgA at dermal papillary tips. Pemphigus vulgaris shows intraepidermal acantholysis with intercellular IgG fishnet pattern. Linear IgA disease shows linear IgA (not IgG) at the BMZ.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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