A 65-year-old woman reports dozens of itchy seborrheic keratoses erupting over her trunk within three months. Evaluation reveals a gastric adenocarcinoma. What is this eponymous sign called?
- A Sister Mary Joseph nodule
- B Trousseau sign
- C Courvoisier sign
- D Sign of Leser-Trelat ✓
Correct answer: D. Sign of Leser-Trelat
Explanation
The sign of Leser-Trelat is the explosive onset of multiple pruritic seborrheic keratoses, classically with an acanthotic border of inflammation, and it is linked mainly to gastric adenocarcinoma. Trousseau sign refers to migratory thrombophlebitis of pancreatic and other visceral cancers, Courvoisier sign is a palpable nontender gallbladder, and a Sister Mary Joseph nodule is an umbilical metastasis.
Reference: Bolognia, Dermatology, 5th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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