Lupus pernio, which is the specific cutaneous marker of sarcoidosis, is characterised by which of the following clinical and histological features?
- A Painful violaceous nodules on nose/ears/cheeks; caseating granulomas
- B Erythematous tender nodules on shins; non-specific panniculitis
- C Non-tender, indurated violaceous plaques on nose/ears/cheeks; non-caseating naked granulomas ✓
- D Annular erythema on trunk; perivascular lymphocytic infiltrate
Correct answer: C. Non-tender, indurated violaceous plaques on nose/ears/cheeks; non-caseating naked granulomas
Explanation
Lupus pernio presents as non-tender, indurated, violaceous-brownish plaques on the nose, cheeks, ears, and lips, often with underlying bone destruction, and correlates with chronic systemic sarcoidosis. Histology shows non-caseating 'naked' (minimal lymphocytic cuff) epithelioid granulomas. Erythema nodosum on shins is the non-specific reactive cutaneous feature of acute sarcoidosis. Caseation is absent (unlike tuberculosis).
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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