Which autoantibody in adult dermatomyositis is most strongly associated with underlying malignancy?
- A Anti-transcription intermediary factor 1 gamma (TIF1-gamma) ✓
- B Anti-Jo-1
- C Anti-Mi-2
- D Anti-NXP2
Correct answer: A. Anti-transcription intermediary factor 1 gamma (TIF1-gamma)
Explanation
Anti-TIF1-gamma (anti-p155/140) antibodies identify the subset of adult dermatomyositis with the highest risk of occult cancer, warranting thorough age-appropriate malignancy screening. Anti-Jo-1 marks antisynthetase syndrome with interstitial lung disease, and anti-Mi-2 is linked to classic severe cutaneous disease with a generally good steroid response. Anti-NXP2 associates more with calcinosis and juvenile disease rather than cancer risk in adults.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.