Morphoea (localized scleroderma) differs from systemic sclerosis in which of the following features?

• A Morphoea involves internal organs including lungs and kidneys
• B Both morphoea and systemic sclerosis show identical immunological profiles
• C Morphoea invariably progresses to systemic sclerosis in 30% of cases
• D Morphoea spares internal organs; Raynaud's phenomenon and sclerodactyly are absent; ANA may be positive in linear/generalized forms but anti-centromere and anti-Scl-70 are typically negative ✓

Explanation

Morphoea is a localized form of scleroderma confined to skin (and subcutaneous tissue in deep morphoea). Unlike systemic sclerosis, it does not affect internal organs, does not cause Raynaud's phenomenon or sclerodactyly. Anti-centromere (CREST) and anti-Scl-70 (diffuse SSc) antibodies are negative. ANA may be positive in 20-40% of generalized/linear morphoea. It does NOT progress to systemic sclerosis. Treatment includes topical/intralesional steroids, phototherapy (UVA1), and methotrexate for extensive/linear forms.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.