Dermatomyositis with heliotrope rash and Gottron's papules is associated with increased risk of malignancy. Which antibody is specifically associated with interstitial lung disease (ILD) in the anti-synthetase syndrome?
- A Anti-Mi-2 antibody
- B Anti-Jo-1 (anti-histidyl-tRNA synthetase) ✓
- C Anti-SRP antibody
- D Anti-TIF1-γ (p155/140) antibody
Correct answer: B. Anti-Jo-1 (anti-histidyl-tRNA synthetase)
Explanation
Anti-Jo-1 (anti-histidyl-tRNA synthetase) is the most common anti-synthetase antibody (present in ~25% of dermatomyositis/polymyositis) and is specifically associated with antisynthetase syndrome: inflammatory myopathy + ILD + mechanic's hands + Raynaud's phenomenon + arthritis. Anti-Mi-2 is associated with classic dermatomyositis with good response to treatment. Anti-TIF1-γ (anti-p155/140) is the antibody most associated with cancer-associated myositis. Anti-SRP is associated with severe immune-mediated necrotising myopathy.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.