Subacute cutaneous lupus erythematosus (SCLE) has a strong association with which anti-nuclear antibody and which drug that most commonly induces SCLE?
- A Anti-dsDNA; hydralazine
- B Anti-Ro/SSA antibodies; hydrochlorothiazide (thiazide diuretics) ✓
- C Anti-histone antibodies; procainamide
- D Anti-Sm antibodies; minocycline
Correct answer: B. Anti-Ro/SSA antibodies; hydrochlorothiazide (thiazide diuretics)
Explanation
SCLE is strongly associated with anti-Ro/SSA antibodies (in ~70% of cases), and anti-La/SSB to a lesser extent. The most common drug-induced SCLE is caused by hydrochlorothiazide (thiazides), followed by proton pump inhibitors, calcium channel blockers, and antifungals. Anti-histone antibodies and hydralazine/procainamide are characteristic of drug-induced systemic LE (not cutaneous LE). Anti-dsDNA is specific for SLE; anti-Sm is also SLE-specific.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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