Anti-Scl-70 (anti-topoisomerase I) antibody in systemic sclerosis is a marker for which subtype and complication?

• A Diffuse cutaneous SSc; pulmonary fibrosis ✓
• B Limited cutaneous SSc; CREST syndrome
• C Overlap syndrome; inflammatory myopathy
• D Localised morphea; no systemic disease

Explanation

Anti-Scl-70 (anti-topoisomerase I) antibody is associated with diffuse cutaneous systemic sclerosis (dcSSc) and predicts risk of interstitial lung disease (pulmonary fibrosis). Anti-centromere antibody (ACA) is associated with limited cutaneous SSc and CREST syndrome (Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasia). Anti-RNA polymerase III antibodies predict scleroderma renal crisis. Anti-PM-Scl antibodies indicate PM/SSc overlap with myopathy.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.