A patient with pemphigus vulgaris produces autoantibodies against desmoglein, a component of desmosomes. Which histological layer of the skin is primarily disrupted by this loss of intercellular adhesion?
- A Stratum corneum
- B Stratum spinosum ✓
- C Stratum basale
- D Stratum granulosum
Correct answer: B. Stratum spinosum
Explanation
Desmosomes are most abundant in the stratum spinosum, giving the cells their spiny appearance. In pemphigus vulgaris, autoantibodies target desmoglein, causing acantholysis primarily in the stratum spinosum. The stratum basale is involved in bullous pemphigoid, which targets hemidesmosomes. Stratum corneum and granulosum are upper layers with fewer desmosomes.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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