Anatomy · Histology (Epithelium, Connective Tissue, Bone, Muscle, Nerve)

In a cross-section of a peripheral nerve, which layer of connective tissue directly invests each individual nerve fiber?

  • A Epineurium
  • B Perineurium
  • C Endoneurium
  • D Mesoneurium
Correct answer: C. Endoneurium

Explanation

The endoneurium is the innermost connective tissue layer of a peripheral nerve and directly surrounds each individual myelinated or unmyelinated nerve fiber along with its Schwann cell sheath. Perineurium (containing myofibroblasts) surrounds fascicles, forming the blood-nerve barrier analogous to the blood-brain barrier. Epineurium is the outermost layer encasing the entire nerve trunk.

Reference: BD Chaurasia's Human Anatomy, 8th ed.

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