A 35-year-old man presents with a testicular mass. Histology shows uniform cells with clear cytoplasm and well-defined cell borders (fried egg appearance). Serum LDH is elevated, but AFP and beta-hCG are normal. What is the diagnosis?

• A Yolk sac tumor
• B Leydig cell tumor
• C Embryonal carcinoma
• D Classic seminoma ✓

Explanation

Classic seminoma features uniform cells with clear cytoplasm and distinct borders (fried egg appearance). It is characteristically associated with elevated LDH and never produces AFP. Yolk sac tumors produce AFP, and embryonal carcinomas often produce beta-hCG or AFP.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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