A 25-year-old man presents with a painless, progressive swelling of the right testis. Ultrasound shows a heterogeneous intratesticular mass. Serum AFP is 800 ng/mL and beta-hCG is normal. The most likely tumour type is:
- A Yolk sac tumour (non-seminomatous germ cell tumour) ✓
- B Seminoma
- C Embryonal carcinoma
- D Teratoma
Correct answer: A. Yolk sac tumour (non-seminomatous germ cell tumour)
Explanation
Markedly elevated AFP with normal beta-hCG points to a yolk sac tumour (endodermal sinus tumour), the main producer of AFP among testicular germ cell tumours. Seminomas never produce AFP. Embryonal carcinoma may raise AFP and beta-hCG together. Teratomas may elevate AFP slightly but not to this degree. The management begins with radical orchidectomy through an inguinal approach, followed by staging CT and chemotherapy if node-positive.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.