The D'Amico risk classification for prostate cancer stratifies patients into low, intermediate, and high risk based on three parameters. A patient with PSA 12 ng/mL, Gleason score 7 (3+4), and clinical stage T2b is classified as:

• A Intermediate risk ✓
• B High risk
• C Low risk
• D Very high risk by EAU classification

Explanation

D'Amico intermediate risk requires any one of: PSA 10–20 ng/mL, Gleason score 7, or clinical stage T2b–T2c. This patient has PSA 12 (intermediate range, 10–20), Gleason 7 (intermediate), and T2b — all three parameters fall in the intermediate range. High risk would require PSA >20, Gleason ≥8, or T3–T4. The presence of multiple intermediate-risk features (unfavourable intermediate) may influence choice of therapy but D'Amico classification overall is intermediate.

Reference: Bailey & Love's Short Practice of Surgery, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.