Which of the following drugs is a well recognised cause of bilateral gynaecomastia?
- A Spironolactone ✓
- B Furosemide
- C Amiloride
- D Metoprolol
Correct answer: A. Spironolactone
Explanation
Spironolactone is a classic cause of painful bilateral gynaecomastia through its antiandrogenic action, displacement of testosterone from sex hormone binding globulin, and increase in peripheral testosterone to estradiol conversion. Furosemide, amiloride and metoprolol have no significant estrogenic or antiandrogenic activity and are not established causes of gynaecomastia in standard texts.
Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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