Which of the following is an absolute contraindication to breast conservation surgery (lumpectomy followed by radiation) for breast carcinoma?

• A Tumor size of 3.5 cm in a large-breasted woman
• B Multicentric disease (tumors in two different quadrants) ✓
• C Positive axillary lymph nodes
• D HER2-positive molecular subtype

Explanation

Multicentric disease (tumors in separate quadrants) is an absolute contraindication to breast conservation because clear margins cannot be achieved with acceptable cosmetic result. A 3.5 cm tumor in a large breast may be amenable to lumpectomy. Positive nodes and HER2 positivity are not contraindications; they guide systemic and radiation therapy but do not preclude breast conservation.

Reference: Bailey and Love's Short Practice of Surgery, 28th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.