A 35-year-old woman with a strong family history of breast and ovarian cancer is found to have a BRCA1 pathogenic variant. She is counseled about risk-reducing bilateral salpingo-oophorectomy. At what age is this procedure typically recommended for BRCA1 mutation carriers?

• A 25 to 30 years
• B 35 to 40 years ✓
• C 45 to 50 years
• D 55 to 60 years

Explanation

For BRCA1 mutation carriers, risk-reducing bilateral salpingo-oophorectomy is recommended between ages 35 and 40, after completion of childbearing. BRCA1 carriers have a higher risk of ovarian cancer at a younger age compared to BRCA2 carriers, for whom the recommendation is ages 40 to 45. The procedure also reduces breast cancer risk by approximately 50 percent.

Reference: Harrison Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.