A 40-year-old woman with a strong family history of breast and ovarian cancer is found to have a pathogenic BRCA1 variant. What is the recommended age to begin annual breast MRI screening according to NCCN guidelines?

• A 40 years
• B 35 years
• C 30 years
• D 25 years ✓

Explanation

NCCN guidelines recommend that women with a known BRCA1 pathogenic variant begin annual breast MRI screening starting at age 25, with the addition of mammography typically from age 30. Starting at 25 reflects the early onset of BRCA1-associated breast cancers, which are often high-grade and triple-negative.

Reference: Harris, Diseases of the Breast, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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