Which statement accurately describes the relationship between lobular carcinoma in situ (LCIS) and invasive breast cancer?

• A LCIS is a direct precursor lesion that progresses to invasive lobular carcinoma in situ over time
• B LCIS is classified as Tis in the TNM staging system
• C LCIS requires the same surgical management as ductal carcinoma in situ with negative margins
• D LCIS confers an equal risk of subsequent invasive cancer in either breast and is considered a risk marker ✓

Explanation

LCIS is a risk marker conferring equal bilateral risk of subsequent invasive cancer rather than a direct precursor lesion. Unlike DCIS, it does not require excision with negative margins as it is not a direct precursor. DCIS is staged as Tis; LCIS is no longer considered a malignancy and is not staged as Tis in the current AJCC system.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.