Which of the following is an absolute contraindication to breast-conserving therapy in a patient with invasive breast carcinoma?
- A Tumor-to-breast size ratio requiring >20% volume excision
- B Multicentric disease in different quadrants ✓
- C Positive family history of BRCA mutation
- D Lobular histology
Correct answer: B. Multicentric disease in different quadrants
Explanation
Multicentric disease (tumors in different quadrants) is an absolute contraindication to breast-conserving surgery as clear margins cannot be achieved while maintaining acceptable cosmesis. B large tumor-to-breast ratio is a relative contraindication. BRCA mutation is not a contraindication, though it may prompt bilateral mastectomy. Lobular histology alone is not a contraindication.
Reference: Sabiston Textbook of Surgery, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.