A 45-year-old premenopausal woman with ER-positive, node-negative breast cancer (T1N0M0) is started on adjuvant endocrine therapy. What is the standard regimen?

• A Tamoxifen for 2 years followed by exemestane
• B Letrozole 2.5 mg daily for 5 years
• C Goserelin alone for 2 years
• D Tamoxifen 20 mg daily for 5 years ✓

Explanation

For premenopausal women with ER-positive breast cancer, tamoxifen 20 mg daily for 5 years remains the standard adjuvant endocrine therapy. Aromatase inhibitors like letrozole are used in postmenopausal women as they require low estrogen levels. Ovarian suppression combined with AI is an option in high-risk premenopausal patients but is not the universal standard.

Reference: Devita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology, 12th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.