Which histological subtype accounts for the vast majority of primary male breast cancers?

• A Invasive lobular carcinoma
• B Invasive ductal carcinoma of no special type ✓
• C Mucinous carcinoma
• D Medullary carcinoma

Explanation

Male breast tissue lacks terminal lobular development under normal hormonal conditions, so invasive ductal carcinoma of no special type makes up about 85 to 90 percent of male breast cancers. Lobular carcinoma is distinctly rare in men because lobules do not form without oestrogen driven differentiation, which kills option A. Male cancers frequently express hormone receptors and BRCA2 mutations are overrepresented.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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