Paget's disease of the nipple is characterised histologically by the presence of large pale cells within the epidermis. These cells most likely originate from:
- A Langerhans cells migrating from dermis
- B In situ ductal carcinoma cells spreading along the epidermis ✓
- C Melanocytes undergoing malignant transformation
- D Toker cells of the nipple epidermis
Correct answer: B. In situ ductal carcinoma cells spreading along the epidermis
Explanation
Paget's disease of the nipple results from intraepidermal spread of malignant cells originating from an underlying ductal carcinoma in situ or invasive carcinoma. The large pale Paget cells (HER2-overexpressing) are identical to the underlying carcinoma cells. Toker cells are normal clear cells of the nipple that can mimic Paget's histologically but are benign.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.