Which molecular subtype of breast cancer is characterized by ER-negative, PR-negative, HER2-negative status, is associated with BRCA1 mutations, and has a basal-like gene expression profile?
- A Luminal A
- B Luminal B
- C Triple-negative (basal-like) ✓
- D HER2-enriched
Correct answer: C. Triple-negative (basal-like)
Explanation
Triple-negative breast cancer (ER-, PR-, HER2-) corresponds to the basal-like molecular subtype and is strongly associated with BRCA1 germline mutations. It has a poor prognosis, high grade, and lacks targetable hormone receptors, making chemotherapy the primary systemic treatment. Luminal A and B subtypes are ER-positive; HER2-enriched overexpresses HER2 but may be ER-negative.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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