Which classification system specifically stratifies breast cancer based on intrinsic molecular subtypes identified by gene expression profiling, including Luminal A, Luminal B, HER2-enriched, and Basal-like?

• A Elston-Ellis grading
• B Perou-Sorlie intrinsic subtype classification ✓
• C Nottingham Prognostic Index
• D St. Gallen consensus classification

Explanation

The Perou-Sorlie classification (2000) used cDNA microarray gene expression profiling to identify four intrinsic breast cancer subtypes: Luminal A, Luminal B, HER2-enriched, and Basal-like. These subtypes have distinct prognosis and treatment implications. Elston-Ellis grades tumors histologically; Nottingham combines grade, nodal status, and tumor size; St. Gallen provides treatment consensus but is not the originator of intrinsic subtype nomenclature.

Reference: Bailey & Love's Short Practice of Surgery, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.