Regarding the Nottingham Prognostic Index (NPI) for breast cancer, which combination of parameters constitutes its calculation?
- A Tumor size × 0.2 + lymph node stage + histological grade ✓
- B Tumor size + ER status + HER2 status
- C Tumor size × 0.2 + number of positive nodes + mitotic index
- D Lymph node stage + histological grade + Ki-67 index
Correct answer: A. Tumor size × 0.2 + lymph node stage + histological grade
Explanation
The Nottingham Prognostic Index = 0.2 × tumor size (cm) + lymph node stage (1=node-negative, 2=1-3 nodes positive, 3=≥4 nodes positive) + histological grade (1=grade I, 2=grade II, 3=grade III). Scores <3.4 indicate a good prognosis; >5.4 indicate poor prognosis. It does not include molecular markers like ER status or Ki-67, distinguishing it from the Oncotype DX or Mammaprint multigene assays.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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