Which molecular subtype of breast cancer is characterised by ER-negative, PR-negative, HER2-negative status and is associated with BRCA1 mutations, basal cytokeratin expression, and a predilection for visceral rather than bone metastases?
- A Luminal A
- B Luminal B
- C Triple-negative (basal-like) ✓
- D HER2-enriched
Correct answer: C. Triple-negative (basal-like)
Explanation
Triple-negative (basal-like) breast cancer is ER/PR/HER2-negative, expresses basal cytokeratins CK5/6 and CK14, and is strongly associated with BRCA1 germline mutations. It preferentially metastasises to viscera and brain rather than bone. Luminal A and B subtypes are ER-positive. HER2-enriched is ER/PR-negative but HER2-positive.
Reference: Bailey & Love's Short Practice of Surgery, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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