A new screening test for a rare genetic disorder has excellent sensitivity and specificity, but the test is invasive, expensive, and has a complication rate of 5%. According to Wilson and Jungner criteria, which factor is most likely to render this test unsuitable for population screening?
- A High cost and invasiveness ✓
- B Low sensitivity
- C Low specificity
- D Long latent period
Correct answer: A. High cost and invasiveness
Explanation
Wilson and Jungner criteria require that a screening test be acceptable, safe, and affordable. High cost and a 5% complication rate violate these principles, making the test unsuitable despite good accuracy. Sensitivity and specificity are already excellent.
Reference: Wilson and Jungner, Principles and Practice of Screening for Disease, WHO, 1968 ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.