In mesothelioma caused by asbestos exposure, the latency period between first exposure and disease manifestation is characteristically:
- A 30–40 years ✓
- B 5–10 years
- C 15–20 years
- D 1–5 years
Correct answer: A. 30–40 years
Explanation
Malignant pleural mesothelioma has a characteristically long latency of 30–40 years (range 20–50 years) between first asbestos exposure and disease onset, which is longer than most other occupational cancers. Amphibole fibers (crocidolite — blue asbestos; amosite — brown asbestos) carry higher mesothelioma risk than chrysotile (white asbestos). This long latency means many current cases reflect industrial exposures from the 1970s-80s. Lung cancer from asbestos has a shorter latency (15–20 years). Mesothelioma can occur even with brief or low-level exposure.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
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