A 6-week-old infant is brought for the first dose of pentavalent vaccine. The mother reports the infant had a seizure 2 days after birth. As per UIP guidelines, which component of the pentavalent vaccine is contraindicated in this scenario?
- A DPT component (specifically the whole-cell pertussis part) ✓
- B Hib component
- C Hepatitis B component
- D None; pentavalent can be given safely
Correct answer: A. DPT component (specifically the whole-cell pertussis part)
Explanation
C history of an evolving neurological condition, including seizures within 72 hours of a previous dose, is a contraindication to the pertussis component of DPT. The whole-cell pertussis vaccine is specifically contraindicated in progressive neurological disorders. Hepatitis B and Hib components have no such contraindication. This is a frequently tested contraindication.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.