The rotavirus vaccine included in the UIP in India is administered orally at 6, 10, and 14 weeks of age. The key reason for NOT administering it after 8 months of age is:

• A Waning maternal antibodies interfere with immunogenicity beyond 8 months
• B Increased risk of intussusception with live oral rotavirus vaccines beyond 8 months ✓
• C The child has already developed natural immunity through asymptomatic infection
• D Cold chain requirements become difficult to maintain beyond 8 months

Explanation

Post-licensure surveillance of the first-generation RotaShield vaccine revealed an increased risk of intussusception when given to older infants (beyond 8 months), likely due to altered immunological responses in the more mature gut. Current rotavirus vaccines (Rotarix, RotaTeq, ROTAVAC, ROTASIIL) are licensed and recommended to complete the series by 8 months of age (upper age limit for last dose) to minimise this risk. Maternal antibodies are a concern for early administration, not late.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.