Inactivated Polio Vaccine (IPV) was introduced into the Universal Immunization Programme as fractional IPV (fIPV) given intradermally. The dose of fIPV given intradermally is what fraction of the standard intramuscular dose?
- A 1/10th (0.1 mL)
- B 1/5th (0.1 mL of 0.5 mL standard) ✓
- C 1/3rd (0.17 mL)
- D 1/2 (0.25 mL)
Correct answer: B. 1/5th (0.1 mL of 0.5 mL standard)
Explanation
Fractional IPV (fIPV) administered intradermally uses one-fifth (1/5) of the standard intramuscular dose: 0.1 mL intradermally versus 0.5 mL intramuscularly. Intradermal delivery exploits the high density of antigen-presenting cells in the dermis, eliciting equivalent immunogenicity with less antigen. This approach conserves vaccine supply and reduces program costs.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.