Which NSAID is specifically used pharmacologically to close a patent ductus arteriosus in a premature neonate?
- A Paracetamol
- B Indomethacin ✓
- C Naproxen
- D Piroxicam
Correct answer: B. Indomethacin
Explanation
Indomethacin inhibits prostaglandin synthesis, removing the vasodilator PGE1 and PGE2 tone that keeps the ductus arteriosus patent in the fetus and premature infant, so the duct constricts and closes. Ibuprofen lysinate is an alternative with fewer renal side effects. The same physiology explains why maternal NSAID use late in pregnancy risks premature closure of the ductus in the fetus. Paracetamol has been tried recently but indomethacin remains the classical answer in Indian exams.
Reference: KD Tripathi Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.