Autacoids & NSAIDs MCQs

Pharmacology · 12 free questions with answers & explanations.

1. A 40-year-old woman with rheumatoid arthritis is switched from diclofenac to celecoxib (a COX-2 selective inhibitor). Which adverse effect profile best distinguishes celecoxib from diclofenac?
2. A patient takes aspirin 75 mg daily for secondary prevention of myocardial infarction. Why is such a low dose sufficient for antiplatelet effect when much higher doses are needed for analgesic and anti-inflammatory effects?
3. A 28-year-old asthmatic woman develops acute bronchospasm, urticaria, and nasal polyps within an hour of taking aspirin for musculoskeletal pain. Her serum IgE is normal. What is the mechanism of this reaction?
4. A patient receiving cisplatin-based chemotherapy develops intractable nausea and vomiting that does not respond to metoclopramide. The oncologist switches to ondansetron. At which receptor does ondansetron exert its primary antiemetic effect?
5. A 35-year-old woman with systemic mastocytosis experiences recurrent episodes of flushing, pruritus, and gastric hypersecretion due to excessive histamine release. Which combination of drugs best addresses both the cutaneous and gastric symptoms simultaneously?
6. A patient taking aspirin for secondary prevention of MI develops sudden-onset hematemesis. Aspirin-induced gastric mucosal damage occurs via which MAIN mechanism beyond direct irritation?
7. Colchicine prevents acute gouty arthritis attacks by:
8. A patient with aspirin-sensitive asthma should also AVOID which of the following drugs due to cross-reactivity?
9. Allopurinol used in chronic gout works by inhibiting which enzyme?
10. Sumatriptan is effective in aborting a migraine attack. Its MAIN mechanism of action is:
11. Paracetamol (acetaminophen) overdose causes hepatotoxicity primarily through which mechanism?
12. A first-generation antihistamine (chlorpheniramine) causes more sedation than a second-generation antihistamine (cetirizine) because: