Which cytokine is the principal stimulus for hepatic synthesis of C-reactive protein and fibrinogen during the acute phase response?

• A IL-12
• B IL-17
• C Interferon gamma
• D IL-6 ✓

Explanation

IL-6, produced by macrophages and other cells at inflammatory sites, acts on hepatocytes to induce the classical acute phase proteins, including CRP, serum amyloid A, fibrinogen and hepcidin. IL-12 and interferon gamma drive Th1 differentiation and macrophage activation rather than hepatic protein synthesis. IL-17 recruits neutrophils. Persistently elevated IL-6 underlies secondary amyloidosis through sustained serum amyloid A production.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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