Leukotriene B4 (LTB4) is a potent chemoattractant derived from arachidonic acid via the 5-lipoxygenase pathway. Its primary cellular target in acute inflammation is:

• A Mast cells, causing degranulation
• B Platelets, causing aggregation
• C Endothelial cells, causing vasoconstriction
• D Neutrophils and monocytes, promoting chemotaxis and activation ✓

Explanation

LTB4 is generated from 5-HPETE by LTA4 hydrolase and acts primarily on neutrophils and monocytes, promoting directional migration (chemotaxis), increased adhesion molecule expression, and respiratory burst. It is among the most potent endogenous neutrophil chemoattractants. LTC4, LTD4, and LTE4 (slow-reacting substances) cause bronchoconstriction and increased vascular permeability; thromboxane A2 causes platelet aggregation and vasoconstriction.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.