A pathologist examining a lymph node biopsy from a patient with granulomatous disease notes epithelioid macrophages and multinucleated giant cells. Worldwide, the most common cause of this pattern is:

• A Sarcoidosis
• B Leprosy
• C Crohn disease
• D Tuberculosis ✓

Explanation

Tuberculosis is the most common cause of epithelioid granulomas globally, especially in endemic regions. Sarcoidosis is common in some populations but less frequent worldwide. Leprosy and Crohn disease are less common causes. The question tests epidemiological awareness in granulomatous inflammation.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.