During the early phase of acute inflammation, which mediator is primarily responsible for the immediate transient increase in vascular permeability?
- A Histamine ✓
- B Bradykinin
- C Leukotriene C4
- D C5a
Correct answer: A. Histamine
Explanation
Histamine released from mast cells causes endothelial cell contraction and gap formation, producing the immediate transient increase in vascular permeability. Bradykinin also increases permeability but acts via a different receptor. Leukotriene C4 and C5a cause a delayed, sustained permeability increase.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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