A patient with a known cyclooxygenase deficiency would have reduced synthesis of which arachidonic acid metabolite that is a potent vasoconstrictor and platelet aggregator?

• A Prostacyclin
• B Prostaglandin E2
• C Leukotriene C4
• D Thromboxane A2 ✓

Explanation

Thromboxane A2 is synthesized via the cyclooxygenase pathway in platelets and causes vasoconstriction and platelet aggregation. Prostacyclin and PGE2 are also COX-derived but have vasodilatory effects. Leukotriene D4 is a lipoxygenase product and acts as a bronchoconstrictor.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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