Which chemokine, acting through its cognate receptor on circulating monocytes, is primarily responsible for recruiting monocytes out of the bloodstream into sites of chronic inflammation?

• A MCP-1 (CCL2), acting on CCR2 ✓
• B IL-8 (CXCL8), acting on CXCR1/2
• C IP-10 (CXCL10), acting on CXCR3
• D Eotaxin (CCL11), acting on CCR3

Explanation

Monocyte chemoattractant protein-1 (MCP-1, CCL2) binds CCR2 constitutively expressed on monocytes and directs their recruitment to chronically inflamed tissues, where they become macrophages. IL-8 is the prototypical neutrophil chemoattractant of acute inflammation. IP-10 attracts activated T cells via CXCR3, and eotaxin recruits eosinophils through CCR3 in allergic and parasitic responses, making each a lineage-mismatched distractor.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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