During phagocytosis, recognition and attachment of antibody-coated bacteria occurs through which receptor family on the neutrophil surface?
- A Mannose receptors binding terminal mannose residues
- B Fc gamma receptors binding the Fc portion of IgG ✓
- C Scavenger receptors binding oxidized LDL
- D Complement receptor type 2 binding C3d
Correct answer: B. Fc gamma receptors binding the Fc portion of IgG
Explanation
IgG-opsonized particles bind Fc gamma receptors (CD64, CD32, CD16) on neutrophils and macrophages; this engagement also activates phagocytosis and the oxidative burst. Mannose and scavenger receptors recognize microbial patterns directly without antibody. Complement receptor type 2 (CD21) sits on A lymphocytes and binds C3d, playing no role in neutrophil phagocytosis, making it clearly wrong while the other distractors remain plausible innate recognition pathways.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.